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Updated: Nov 17, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Neonatal Renal Tumors.

Sei-Gyung K Sze¹

¹Maine Children's Cancer Program, Department of Pediatrics, Maine Medical Center, Tufts School of Medicine, 100 Campus Drive, Suite 107, Scarborough, ME 04074, USA.

Clinics in Perinatology

|February 15, 2021

Summary

Neonatal renal tumors are rare but often present as abdominal masses. Diagnosis and treatment involve imaging and radical nephrectomy for common types in newborns.

Area of Science:

Pediatric Oncology
Neonatal Surgery
Urologic Pathology

Background:

Renal tumors are uncommon in newborns.
Presentation often includes palpable abdominal masses.
Prenatal detection occurs but postnatal presentation is more frequent.

Purpose of the Study:

To review clinical presentation, diagnosis, treatment, and outcomes of neonatal renal tumors.
To discuss common renal tumor types in the neonatal population.
To guide management strategies for these rare malignancies.

Main Methods:

Review of clinical data for neonates with renal tumors.
Analysis of diagnostic imaging techniques.
Evaluation of surgical and therapeutic interventions.

Keywords:

Clear cell sarcoma of the kidney Congenital mesoblastic nephroma Malignant rhabdoid tumor of the kidney Neonatal Wilms tumor

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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Published on: April 12, 2017

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Published on: November 22, 2019

Histologic diagnosis following radical nephrectomy.

Main Results:

Common presentation is a palpable abdominal mass.
Cross-sectional imaging is crucial for diagnosis.
Radical nephrectomy is standard for diagnosis and initial treatment.
Outcomes vary based on tumor type and stage.

Conclusions:

Neonatal renal tumors require prompt diagnosis and management.
Multidisciplinary approach is essential for optimal outcomes.
Further research into specific tumor biology and targeted therapies is warranted.