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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Updated: Nov 17, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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Cutaneous Cancer Biology.

Alok R Khandelwal1, Kristen A Echanique2, Maie St John3

  • 1Department of Otolaryngology, Head and Neck Surgery, LSU Health Sciences Center, Shreveport, LA 71130, USA.

Otolaryngologic Clinics of North America
|February 15, 2021
PubMed
Summary
This summary is machine-generated.

Skin cancer incidence is rising globally. This review explores the biology, pathogenesis, and targeted therapies for nonmelanoma skin cancer (NMSC) and melanoma, aiding prognosis and treatment.

Keywords:
Basal cell carcinomaCutaneous skin cancerHead and neck cancerMelanomaMerkel cell carcinomaSquamous cell carcinoma

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Area of Science:

  • Dermatology and Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Global incidence of nonmelanoma skin cancer (NMSC), including squamous cell carcinoma, basal cell carcinoma, and melanoma, is increasing.
  • While most skin cancers are surgically treatable, advanced cases (fewer than 10%) necessitate further therapeutic interventions.
  • Enhanced understanding of skin cancer biology is crucial for improved prognostication and the discovery of novel therapeutic targets.

Purpose of the Study:

  • To review the fundamental biology and pathogenesis of NMSC and melanoma.
  • To highlight critical cell signaling pathways involved in skin cancer development.
  • To discuss current therapeutic strategies targeting specific genetic pathways in skin cancer.

Main Methods:

  • Literature review of scientific articles on skin cancer biology and treatment.
  • Analysis of key cell signaling pathways implicated in NMSC and melanoma.
  • Synthesis of information on current and emerging therapeutic strategies.

Main Results:

  • Detailed overview of the molecular mechanisms driving NMSC and melanoma.
  • Identification of critical signaling pathways (e.g., Wnt, Hedgehog, MAPK) in skin carcinogenesis.
  • Summary of targeted therapies based on genetic mutations and pathway dysregulation.

Conclusions:

  • A comprehensive understanding of skin cancer biology is essential for advancing patient care.
  • Targeted therapies focusing on specific molecular pathways offer promising treatment avenues for advanced NMSC and melanoma.
  • Further research into skin cancer pathogenesis will likely yield new prognostic markers and therapeutic targets.