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Related Experiment Videos

Platinum concentrations in human autopsy tumor samples.

D J Stewart1, N Z Mikhael, R C Nair

  • 1Ontario Cancer Treatment and Research Foundation, Ottawa Regional Cancer Centre, Canada.

American Journal of Clinical Oncology
|April 1, 1988
PubMed
Summary

Platinum accumulates in tumors, with higher concentrations found in liver metastases. Factors like time since treatment and cumulative dose influence platinum levels, which correlate with treatment response.

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Area of Science:

  • Oncology
  • Pharmacokinetics
  • Cancer Research

Background:

  • Cisplatin is a widely used platinum-based chemotherapy agent.
  • Understanding platinum distribution in tumors is crucial for optimizing treatment efficacy.
  • Tumor platinum concentrations can vary significantly based on several factors.

Purpose of the Study:

  • To quantify platinum concentrations in autopsy tumor samples.
  • To identify factors influencing platinum accumulation in various tumor types.
  • To explore the relationship between tumor platinum levels and treatment response.

Main Methods:

  • Autopsy tumor samples from 27 patients treated with cisplatin were analyzed.
  • Platinum concentrations were measured in different tumor sites and normal liver tissue.

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  • Multiple stepwise linear regression was used to identify predictive factors.

    • Main Results:

    • Liver metastases showed significantly higher platinum concentrations compared to other tumor sites.
    • Platinum levels in gliomas and brain metastases were comparable to other extrahepatic tumors.
    • Tumor platinum concentration was independently associated with time since last treatment, cumulative dose, administration route, and tumor site.

    Conclusions:

    • Platinum distribution in tumors is site-dependent, with preferential accumulation in liver metastases.
    • Key factors influencing tumor platinum levels include treatment history and administration route.
    • Higher tumor platinum concentrations are associated with a positive response to cisplatin-based chemotherapy.