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Updated: Nov 17, 2025

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction
Published on: August 9, 2011
Stunning symmetries involved in the self-assembly of the HSV-1 capsid
Joo-Hyeon Lee1, Jaehyu Shim1, Seung Joong Kim1,2
1Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141 Korea.
Abstract:
Herpes simplex virus-1 (HSV-1) is an enveloped dsDNA virus, infecting ~ 67% of humans. Here, we present the essential components of the HSV-1, focusing on stunning symmetries on the capsid. However, little is known about how the symmetries are involved dynamically in the self-assembly process. We suggest small angle X-ray scattering as a suitable method to capture the dynamics of self-assembly. Furthermore, our understanding of the viruses can be expanded by using an integrative approach that combines heterogeneous types of data, thus promoting new diagnostic tools and a cure for viral infections.
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