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Jaundice in neonates with sickle cell disease. A case-control study
R Bainbridge1, J Khoury, F Mimouni
1Department of Pediatrics, University of Cincinnati, OH.
American Journal of Diseases of Children (1960)
|May 1, 1988
Summary
Sickle cell disease (SCD) does not increase the risk of neonatal jaundice. This study found no significant difference in jaundice rates or bilirubin levels in infants with SCD compared to controls.
Area of Science:
- Neonatology
- Hematology
- Pediatrics
Background:
- Previous studies suggested a link between sickle cell disease (SCD) and neonatal jaundice.
- Uncontrolled studies indicated a high incidence of jaundice in neonates with SCD.
Purpose of the Study:
- To investigate the hypothesis that sickle cell disease (SCD) contributes to neonatal jaundice.
- To determine if SCD is a significant predisposing factor for neonatal jaundice.
Main Methods:
- A matched case-control study involving 68 neonates with SCD.
- Controls were matched for gestational age, sex, birth weight, and race.
- Serum bilirubin levels and clinical jaundice were assessed, along with potential confounding factors.
Main Results:
- No increased rate of clinical jaundice was observed in neonates with SCD compared to controls.
- Serum bilirubin concentrations were not significantly higher in infants with SCD.
- Subgroup analyses for homozygous SCD and S-hemoglobin C disease also showed no increased jaundice risk.
Conclusions:
- Sickle cell disease (SCD) is unlikely to be a significant factor predisposing to neonatal jaundice.
- The findings challenge previous assumptions about the relationship between SCD and neonatal jaundice.