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Updated: Nov 17, 2025
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Protective Effect of Xinmailong Injection on Rats With Myocardial Infarction
Wei Zhang1, Kailiang Li1, Yu Ding1
1Geriatric Cardiology Department of the Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Insights
Xinmailong injection demonstrated significant cardioprotective effects in rats with myocardial infarction. It reduced inflammation and myocardial damage, improving cardiac function comparable to sodium creatine phosphate.
Area of Science:
- Cardiology
- Pharmacology
- Biomedical Research
Background:
- Myocardial infarction (MI) poses a significant health burden.
- Novel therapeutic agents are needed to mitigate cardiac damage and improve outcomes post-MI.
Purpose of the Study:
- To evaluate the cardioprotective effects of Xinmailong injection in a rat model of myocardial infarction.
- To compare the efficacy of Xinmailong with sodium creatine phosphate, a known cardioprotective agent.
Main Methods:
- Myocardial infarction was induced in rats.
- Rats received intraperitoneal injections of Xinmailong, sodium creatine phosphate, or saline for 14 days.
- Hemodynamic parameters, blood markers (routine, coagulation, liver/kidney function, inflammatory, myocardial), and cardiac morphology were assessed.
Main Results:
- Xinmailong treatment significantly reduced inflammatory markers and myocardial injury indicators.
- Cardiac function was markedly improved in the Xinmailong group.
- Histological examination revealed Xinmailong protected cardiomyocyte structure and reduced damage, similar to sodium creatine phosphate.
Conclusions:
- Xinmailong injection is safe and exhibits anti-inflammatory, cardiac-improving, and myocardial-protective properties.
- Its efficacy in treating myocardial infarction is comparable to sodium creatine phosphate.
Abstract:
This study aimed to investigate the protective effect of Xinmailong injection on rats with myocardial infarction. Thirty-six rats were induced myocardial infarction by operation, and six underwent sham operation. The myocardial infarction rats were randomly divided into three groups, 12 in each, and administered intraperitoneal injection of Xinmailong 5 mg/(kg·d), sodium creatine phosphate 80 mg/(kg·d), or normal saline as control respectively for 14 days. When the treatments were completed, the hemodynamic parameters of the rats were observed, and blood samples were taken to examine blood routine, blood coagulation index, liver and kidney function, inflammatory index, myocardial marker, thrombo-elastography, and other indicators. The morphology of cardiomyocytes was observed through light microscopy, and the microstructure of the myocardial cells was observed under electron microscope. No significant difference was found in blood routine, liver and kidney function, and blood coagulation index between the Xinmailong and sodium creatine phosphate groups compared with the saline control group. However, the inflammatory index and levels of myocardial markers were significantly decreased, and cardiac function was significantly improved. In terms of the morphology of myocardial cells, the Xinmailong group was similar to the sodium creatine phosphate group, the myocardial cell membrane was protected, and myocardial cell damage was reduced. In conclusion, Xinmailong is safe and had anti-inflammatory, heart-improving, and myocardial-protective effects. Its effectiveness is not inferior to that of sodium creatine phosphate.
