Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

4.4K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Outcomes of Isolated Subarachnoid Hemorrhage after Mechanical Thrombectomy.

AJNR. American journal of neuroradiology·2026
Same author

Treatment of Idiopathic Intracranial Hypertension With Bilateral Trans-stenotic Pressure Gradients: Unilateral Versus Bilateral Venous Sinus Stenting.

Neurosurgery·2026
Same author

An initial machine learning model applied to local field potential data from the subthalamic nucleus to detect freezing of gait in Parkinson's disease.

Frontiers in neurology·2026
Same author

Direct Versus Indirect Bypass in Early-Stage Moyamoya (Suzuki I-III): A Propensity Score-Weighted Study.

Translational stroke research·2026
Same author

Response to: Comment on 'Risk prediction in spine surgery: a scoping review of traditional models, artificial intelligence, and the challenge of clinical translation'.

Spine deformity·2026
Same author

How Expensive is ENT Surgeons' Involvement in Retrosigmoid Craniotomies? A Time-Driven Activity-Based Cost Analysis.

Journal of neurological surgery. Part B, Skull base·2026
Same journal

Topic: Evaluation and Treatment of Social Isolation and Loneliness: Evidence-based Recommendations for Stroke and Neurological Rehabilitation.

Current physical medicine and rehabilitation reports·2026
Same journal

A Narrative Review of Prosthesis Design Decision Making After Lower-Limb Amputation for Developing Shared Decision-Making Resources.

Current physical medicine and rehabilitation reports·2025
Same journal

The Current State and Future Directions of Swallowing Care in Amyotrophic Lateral Sclerosis.

Current physical medicine and rehabilitation reports·2025
Same journal

Preliminary evidence on the effects of exercise on tumor biology: a potential guide for prescribing exercise.

Current physical medicine and rehabilitation reports·2025
Same journal

Dysphagia in Parkinson Disease: Part II-Current Treatment Options and Insights from Animal Research.

Current physical medicine and rehabilitation reports·2024
Same journal

Brain Injury: How Dietary Patterns Impact Long-Term Outcomes.

Current physical medicine and rehabilitation reports·2023
See all related articles

Related Experiment Video

Updated: Nov 17, 2025

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

29.6K

Cerebellar Neuromodulation for Stroke.

Jessica Cooperrider1, Arbaz Momin1, Kenneth B Baker2

  • 1Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio 44195.

Current Physical Medicine and Rehabilitation Reports
|February 15, 2021
PubMed
Summary
This summary is machine-generated.

Cerebellar deep brain stimulation shows promise for stroke rehabilitation. Preclinical studies in rodents demonstrate effectiveness, and early clinical trials for dentate nucleus stimulation are encouraging for motor recovery.

Keywords:
cerebellar stimulationdeep brain stimulationdentate nucleusneurorehabilitationstroke

More Related Videos

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.1K
A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation
11:06

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation

Published on: April 12, 2016

10.7K

Related Experiment Videos

Last Updated: Nov 17, 2025

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
11:47

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum

Published on: February 15, 2015

29.6K
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

1.1K
A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation
11:06

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation

Published on: April 12, 2016

10.7K

Area of Science:

  • Neuroscience
  • Neurosurgery
  • Rehabilitation Medicine

Background:

  • Stroke remains a leading cause of long-term disability, necessitating novel rehabilitation strategies.
  • Cerebellar deep brain stimulation (DBS) is an emerging therapeutic approach for post-stroke recovery.

Purpose of the Study:

  • To review preclinical and clinical evidence for cerebellar DBS in stroke rehabilitation.
  • To evaluate the potential of dentate nucleus stimulation for improving motor function after stroke.

Main Methods:

  • Review of preclinical studies in rodent models demonstrating the efficacy of cerebellar stimulation.
  • Analysis of ongoing Phase I clinical trials investigating dentate nucleus DBS for hemiparesis.

Main Results:

  • Preclinical evidence confirms cerebellar stimulation enhances functional motor recovery in rodent stroke models.
  • Mechanisms may involve synaptogenesis, neurogenesis, and cortical vicariation.
  • Early results from a Phase I clinical trial for dentate nucleus stimulation are encouraging.

Conclusions:

  • Cerebellar DBS, particularly targeting the dentate nucleus, shows significant potential for promoting motor recovery post-stroke.
  • Substantial preclinical data support its therapeutic value, with clinical trials yielding promising initial outcomes.