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Updated: Nov 17, 2025
Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
Published on: February 15, 2015
Cerebellar Neuromodulation for Stroke
Jessica Cooperrider1, Arbaz Momin1, Kenneth B Baker2
1Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio 44195.
Purpose Of Review:
This paper reviews the current preclinical and clinical evidence for cerebellar deep brain stimulation for stroke rehabilitation.
Recent Findings:
We have demonstrated the effectiveness of cerebellar stimulation for stroke rehabilitation in rodent models, which has been reproduced by other groups. Synaptogenesis, neurogenesis, and vicariation of function in the perilesional cortex likely contribute to the mechanistic underpinnings of the effectiveness of this therapy. A Phase I clinical trial investigating dentate nucleus stimulation for improvement of hemiparesis due to stroke is currently underway, and results thus far are encouraging.
Summary:
Activation of the rodent cerebellar dentate nucleus promotes functional motor recovery following stroke. Although results of a Phase I clinical trial are pending, substantial preclinical evidence indicates that deep brain stimulation of the dentate nucleus is a promising therapeutic modality.
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