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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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The Thyroid Gland01:23

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Etiological Association Between Psoriasis and Thyroid Diseases.

Srilatha Eapi1, Rupak Chowdhury2, Odunayo S Lawal3

  • 1Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Cureus
|February 15, 2021
PubMed
Summary

Psoriasis, an autoimmune skin disease, is linked to thyroid conditions like Hashimoto's and Grave's disease, particularly in obese individuals. Further research is needed to understand this connection and develop unified treatments.

Keywords:
autoimmunityhypothyroidismpropylthiouracilpsoriasispsoriatic arthiritisthyroid function tests

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Area of Science:

  • Autoimmune diseases
  • Dermatology
  • Endocrinology

Background:

  • Psoriasis is a chronic autoimmune condition affecting skin and nails.
  • It frequently co-occurs with other autoimmune disorders, including thyroid diseases such as Hashimoto's thyroiditis and Grave's disease.
  • These thyroid conditions impact major organs and bodily functions.

Purpose of the Study:

  • To conduct an in-depth analysis of the association between psoriasis and thyroid diseases.
  • To explore common etiological factors and the role of autoimmunity in this relationship.
  • To review existing literature on the connection between psoriasis and thyroid autoimmunity.

Main Methods:

  • A comprehensive literature search was performed on PubMed.
  • Both regular and Medical Subject Headings (MeSH) keywords were utilized.
  • Forty-five relevant articles were selected for analysis.

Main Results:

  • A positive association between psoriasis and thyroid diseases was observed in most reviewed articles.
  • This association appears more prevalent in patients with obesity and late-onset psoriasis.
  • Some studies indicated no significant connection, highlighting the need for more research.

Conclusions:

  • While a link between psoriasis and thyroid diseases is suggested, concrete explanations are limited due to insufficient research.
  • Additional studies are crucial to elucidate the underlying mechanisms.
  • Clinicians and researchers should consider integrated care, including thyroid evaluation for psoriasis patients, potentially leading to more efficient treatment strategies.