Related Experiment Video
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07:34
Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma
Published on: August 3, 2022
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Therapeutic plasma exchange for persistent encephalopathy associated with Covid-19
Chakrapani Ranganathan1, Shelley D Fusinski1, Imad M Obeid2
1Ascension Macomb-Oakland Hospital, Neurology, USA.
Eneurologicalsci
|February 15, 2021
Summary
Persistent Post COVID Encephalopathy, a disabling neurological condition, may improve with Therapeutic Plasma Exchange (TPE). This study suggests TPE could be a viable treatment for this post-viral syndrome.
Area of Science:
- Neurology
- Infectious Diseases
- Critical Care Medicine
Background:
- COVID-19 infection can cause a wide range of symptoms, including central nervous system (CNS) dysfunction.
- Persistent severe encephalopathy is a disabling neurological manifestation observed weeks after acute COVID-19 illness resolution.
- The exact cause of Post COVID Encephalopathy remains unclear, with theories including viral invasion, thrombosis, and inflammation.
Observation:
- A case series of three patients with persistent Post COVID Encephalopathy is presented.
- These patients underwent Therapeutic Plasma Exchange (TPE) using salinized albumin.
- A positive therapeutic effect was observed in the treated patients.
Findings:
- Therapeutic Plasma Exchange (TPE) with salinized albumin showed a potential positive effect in managing persistent Post COVID Encephalopathy.
- The study highlights the need for further investigation into TPE as a treatment modality.
- Current treatment options for Post COVID Encephalopathy are limited.
Implications:
- The findings suggest that TPE could be a promising therapeutic option for patients suffering from persistent neurological deficits after COVID-19.
- Further research, including prospective randomized trials, is warranted to validate these preliminary results.
- This could lead to the development of specific treatments for Post COVID Encephalopathy syndrome.
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