Transpathology: molecular imaging-based pathology.

Area of Science:

• Medical Imaging
• Pathology
• Biomedical Engineering

Background:

• Pathology, the study of disease, is crucial for medicine but faces limitations like invasiveness and sample representativeness.
• Molecular imaging provides a noninvasive method to visualize molecular and cellular processes in vivo.
• Advancements in molecular imaging technology are enhancing the evaluation of pathophysiological changes.

Purpose of the Study:

• To introduce a novel pathophysiology visualization system based on molecular imaging.
• To explore the potential of molecular imaging to reform pathological practices.
• To highlight the benefits of "transpathology" in disease understanding and precision medicine.

Main Methods:

• Utilizing molecular imaging techniques for noninvasive visualization of biological processes.
• Developing new approaches for trans-scale imaging and tissue transparency.
• Integrating molecular imaging data to bridge basic research and clinical applications.

Main Results:

• Molecular imaging enables precise evaluation of pathophysiological changes.
• The proposed "transpathology" system facilitates multiscale assessment of diseases.
• Tissue transparency techniques enhance the visualization of underlying pathological information.

Conclusions:

• Molecular imaging-based pathophysiology visualization systems hold great potential to transform pathology.
• "Transpathology" supports a multiscale perspective for deciphering disease mechanisms.
• This approach is expected to significantly advance precision medicine.