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Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Related Experiment Video

Updated: Nov 17, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Lymphatic malformations: a 20-year single institution experience.

Anthony P Kronfli1, Christopher J McLaughlin2, Annie E Moroco3

  • 1Department of Surgery, Milton S. Hershey Medical Center, The Pennsylvania State University, 500 University Drive, P. O. Box 850, Hershey, PA, 17033-0850, USA. akronfli@pennstatehealth.psu.edu.

Pediatric Surgery International
|February 15, 2021
PubMed
Summary
This summary is machine-generated.

Lymphatic malformations (LMs) present diversely, with head/neck being most common and prone to recurrence. A specialized clinic aids in managing larger LMs in younger patients, highlighting the need for multidisciplinary care.

Keywords:
Lymphatic malformationsMultidisciplinary care

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Area of Science:

  • Vascular Surgery
  • Pediatric Surgery
  • Congenital Malformations

Background:

  • Lymphatic malformations (LMs) are congenital anomalies arising from lymphatic system development disturbances.
  • Understanding their characteristics and treatment in rural settings is crucial for effective management.

Purpose of the Study:

  • To determine LM characteristics and treatment patterns in a rural tertiary care setting.
  • To evaluate the impact of a specialized vascular malformations clinic on LM patient triage and follow-up.

Main Methods:

  • Retrospective cohort study of 62 patients with LMs.
  • Chart review for demographic, treatment (surgery/sclerotherapy), and follow-up data.

Main Results:

  • Head/neck LMs were most frequent (41.9%) and had the highest recurrence rate (73%).
  • Specialty clinic patients were younger (p=0.030) and had larger average LM volumes (73.2 cm³ vs 14.8 cm³).
  • Treatment included non-surgical management (28), surgery (21), sclerotherapy (7), or both (6).

Conclusions:

  • LM clinical presentations are varied, necessitating a multidisciplinary approach.
  • Collaborative subspecialty care is essential for prompt and effective LM treatment.