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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Changes in antimicrobial resistance and outcomes of health care-associated infections
Mehtap Aydın1, Emel Azak2, Hüseyin Bilgin3
1Department of Infectious Diseases and Clinical Microbiology, Umraniye Research and Training Hospital University of Health Science, Elmalıkent, Adem Yavuz Cd., 34764, Ümraniye/İstanbul, Turkey. mehtapaydin10@gmail.com.
Abstract:
To describe the change in the epidemiology of health care-associated infections (HAI), resistance and predictors of fatality we conducted a nationwide study in 24 hospitals between 2015 and 2018. The 30-day fatality rate was 22% in 2015 and increased to 25% in 2018. In BSI, a significant increasing trend was observed for Candida and Enterococcus. The highest rate of 30-day fatality was detected among the patients with pneumonia (32%). In pneumonia, Pseudomonas infections increased in 2018. Colistin resistance increased and significantly associated with 30-day fatality in Pseudomonas infections. Among S. aureus methicillin, resistance increased from 31 to 41%.
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