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Published on: May 19, 2020
Peripheral Nervous System Manifestations Associated with COVID-19
Sasan Andalib1, José Biller2, Mario Di Napoli3
1Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, Odense University Hospital, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Coronavirus disease (COVID-19) can affect the peripheral nervous system (PNS), causing nerve pain, muscle injury, and neurological disorders like Guillain-Barré syndrome. This review details the broad spectrum of PNS manifestations linked to SARS-CoV-2 infection.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, presents with complex syndromic features.
- Beyond central nervous system involvement, emerging evidence indicates significant peripheral nervous system (PNS) complications associated with COVID-19.
Purpose of the Study:
- To comprehensively review the diverse peripheral nervous system manifestations observed in patients with COVID-19.
- To elucidate the spectrum of neurological and neuromuscular disorders linked to SARS-CoV-2 infection.
Main Methods:
- Systematic literature review of reported PNS manifestations in COVID-19 patients.
- Analysis of clinical presentations and potential pathomechanisms of SARS-CoV-2-induced neuropathy.
Main Results:
- Reported PNS manifestations include nerve pain, skeletal muscle injury, Guillain-Barré syndrome, cranial polyneuritis, neuromuscular junction disorders, neuro-ophthalmological issues, hearing loss, and dysautonomia.
- PNS involvement may stem from immune system dysregulation triggered by SARS-CoV-2 infection.
Conclusions:
- COVID-19 is associated with a wide array of peripheral nervous system disorders.
- Understanding these PNS manifestations is crucial for comprehensive patient management and research into SARS-CoV-2 pathogenesis.
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