Application of micronised acellular dermal matrix for primary premature ejaculation: A preliminary study

Area of Science:

• Urology
• Regenerative Medicine
• Sexual Health

Background:

• Premature ejaculation (PE) is a common sexual dysfunction affecting many men.
• Current treatments for PE have limitations, necessitating novel therapeutic approaches.

Purpose of the Study:

• To evaluate the efficacy and safety of injecting micronised acellular dermal matrix (MADM) particles for primary premature ejaculation.
• To assess the impact of MADM particle injections on intravaginal ejaculation latency time (IELT) and patient-reported outcomes.

Main Methods:

• A prospective single-arm clinical trial involving 30 patients with primary PE.
• MADM particles mixed with platelet-rich plasma were injected into Buck's fascia over the dorsal penile nerve.
• IELT, premature ejaculation diagnostic tool (PEDT) scores, and sexual partner satisfaction were assessed pre- and post-treatment.

Main Results:

• Mean IELT significantly increased from 0.72 min pre-surgery to 2.89 min at 20 weeks post-surgery.
• Significant improvements were observed in PEDT values and sexual partner satisfaction.
• No complications such as infections or allergies were reported, indicating a favorable safety profile.

Conclusions:

• Injection of MADM particles is a safe, effective, and simple treatment option for primary premature ejaculation.
• The procedure offers a promising therapeutic strategy for improving sexual function and quality of life in patients with PE.