Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.1K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.1K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

74
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
74
Drug Delivery: Overview01:16

Drug Delivery: Overview

553
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
553
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

392
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
392
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.2K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.2K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

601
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
601

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the Therapeutic Potential of Nobiletin in Nonsmall Cell Lung Cancer.

BioMed research international·2026
Same author

Micro- and nanoencapsulation strategies for mefenamic acid delivery: carrier design, release mechanisms, and preclinical performance.

Journal of microencapsulation·2026
Same author

The central role of EMT in tumor progression: mechanistic drivers, biomarker discovery, and therapeutic horizons.

Frontiers in pharmacology·2026
Same author

Nanoliposomes based drug delivery for the treatment of various types of cancers: current trends and future perspectives.

Journal of liposome research·2026
Same author

Nanocarriers for lung health: ameliorating inflammation and cell aging using flavonoid-based nano nutrients.

Immunopharmacology and immunotoxicology·2026
Same author

Ubiquitin-specific proteases in Atherosclerosis: Exploring novel therapeutic strategies beyond conventional approaches.

European journal of pharmacology·2026

Related Experiment Video

Updated: Nov 17, 2025

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
06:34

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices

Published on: November 29, 2024

445

Therapeutic delivery with V-amylose.

Parteek Prasher1,2, Rabab Fatima1, Mousmee Sharma2,3

  • 1Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun, India.

Drug Development Research
|February 15, 2021
PubMed
Summary

V-amylose

Keywords:
amylosecontrolled releaseencapsulation

More Related Videos

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

8.2K
Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids
07:14

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Published on: May 16, 2025

415

Related Experiment Videos

Last Updated: Nov 17, 2025

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
06:34

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices

Published on: November 29, 2024

445
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

8.2K
Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids
07:14

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Published on: May 16, 2025

415

Area of Science:

  • Biochemistry
  • Materials Science
  • Drug Delivery

Background:

  • V-amylose exhibits a unique helical structure with a hydrophobic cavity and hydrophilic periphery.
  • This structure facilitates superior encapsulation of amphiphilic/hydrophobic molecules compared to other polysaccharides.
  • V-amylose possesses inherent biocompatibility, biodegradability, and non-immunogenic properties.

Purpose of the Study:

  • To highlight the distinguished features of V-amylose as a potential drug delivery vehicle.
  • To explore the encapsulation and release mechanisms of V-amylose for therapeutic applications.
  • To emphasize the advantages of V-amylose over conventional drug delivery systems.

Main Methods:

  • Structural analysis of V-amylose helix formation.
  • Investigation of encapsulation mechanisms (van der Waals forces, hydrogen bonding).
  • Assessment of resistance to enzymatic hydrolysis and drug release profiles.

Main Results:

  • V-amylose demonstrates superior encapsulation affinity for hydrophobic molecules.
  • High loading efficiency, targeted delivery, and controlled release of drugs are achievable.
  • The helical structure provides resistance to amylase digestion, enabling enzyme-sensitive release.
  • Inclusion complexes formed by V-amylose enhance absorption of high clogP drugs.

Conclusions:

  • V-amylose is a promising polysaccharide for advanced drug delivery systems.
  • Its unique helical structure and properties support efficient nanoencapsulation and controlled release.
  • V-amylose offers a biocompatible and biodegradable platform for oral and colon-specific drug delivery.