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Miniaturized Needle Array-Mediated Drug Delivery Accelerates Wound Healing.

Mohamadmahdi Samandari1, Fariba Aghabaglou2, Kristo Nuutila3

  • 1Department of Biomedical Engineering, University of Connecticut, Farmington, CT, 06030, USA.

Advanced Healthcare Materials
|February 15, 2021
PubMed
Summary

Specialty drug delivery systems significantly improve wound healing by enhancing vascular endothelial growth factor (VEGF) distribution. Intradermal delivery using miniaturized needle arrays (MNAs) shows promise in preclinical models.

Keywords:
VEGFintradermal drug deliveryminiaturized needle arrayswound contractionwound healing

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Insufficient vascularization is a key barrier to normal wound healing, leading to hypoxia and impaired tissue repair.
  • Vascular Endothelial Growth Factor (VEGF) shows potential for promoting wound healing, but its effectiveness is limited by delivery methods.
  • Optimizing drug distribution within the wound bed is crucial for enhancing therapeutic outcomes.

Purpose of the Study:

  • To compare the efficacy of two intradermal drug delivery systems, miniaturized needle arrays (MNAs) and liquid jet injectors (LJIs), for delivering VEGF into wound beds.
  • To evaluate the impact of targeted VEGF delivery on wound healing rates and quality in preclinical models.
  • To assess the translational feasibility of MNA-based VEGF delivery for improving wound repair.

Main Methods:

  • In vitro and in vivo assessments of VEGF distribution and penetration depth using MNAs and LJIs.
  • Evaluation of wound healing in a diabetic murine model following intradermal VEGF administration.
  • Assessment of MNA-based VEGF delivery in a porcine wound healing model.

Main Results:

  • Significant differences in drug penetration depth and tissue distribution were observed between MNAs and LJIs.
  • Intradermal VEGF delivery accelerated wound healing in a diabetic murine model compared to topical administration.
  • VEGF delivery via MNAs in a porcine model resulted in enhanced angiogenesis, reduced wound contraction, and increased tissue regeneration.

Conclusions:

  • The choice of drug delivery system critically influences the effectiveness of VEGF therapy for wound healing.
  • Intradermal delivery, particularly using MNAs, offers a superior strategy for improving angiogenesis and promoting tissue regeneration.
  • Combining effective therapeutics with optimized delivery systems is essential for advancing wound healing strategies.