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[About the use of ketamine in emergency psychiatric settings]
Ioannis Sergentanis1, Vincent Vibert1, Alessandra Costanza2,3
1Unité d'accueil et d'urgences psychiatriques, Service des urgences, Département de médecine aiguë, HUG, 1211 Genève 14.
Abstract:
Ketamine and its S-enantiomer, esketamine, have shown to be promising molecules for use in psychiatry. Widely investigated for the treatment of drug-resistant depression, they could be used in emergency conditions, due to their rapid onset of action, in two main conditions : 1) psychomotor agitation, and 2) acute suicidal ideation and behavior (suicidal crisis). In particular, intranasal administration offers a non-invasive, safe and very easy to administer option. An effect begins a few hours to a day after intake and lasts for about a week. These molecules present an innovative option for the future and their specific use in psychiatric emergencies.
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