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Active Giant Cell Vasculitis Diagnosis with 68Ga PSMA PET/CT Imaging

Muhammet Sait Sağer1, Seçkin Bilgiç1, Lebriz Uslu1

  • 1İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Nuclear Medicine, İstanbul, Turkey.

Molecular Imaging and Radionuclide Therapy
|February 15, 2021
PubMed

Insights

Giant cell arteritis (GCA), a form of vasculitis, can show uptake on Gallium-68 PSMA PET/CT scans. This finding is important as PSMA PET/CT is typically used for prostate cancer imaging.

Area of Science:

  • Nuclear medicine
  • Radiology
  • Immunology

Background:

  • Vasculitis involves blood vessel inflammation.
  • Giant cell arteritis (GCA) commonly affects large arteries.
  • 18F-FDG PET/CT is established for GCA diagnosis.

Purpose of the Study:

  • To investigate PSMA uptake in GCA.
  • To assess the utility of Gallium-68 PSMA PET/CT in GCA.

Main Methods:

  • Utilized Gallium-68 PSMA PET/CT imaging.
  • Analyzed PSMA uptake patterns in patients with GCA.

Main Results:

  • Demonstrated increased PSMA uptake in GCA.
  • Identified PSMA uptake as a potential finding in GCA, distinct from its typical use in prostate cancer.

Conclusions:

  • PSMA PET/CT can reveal uptake in GCA.
  • This finding broadens the understanding of PSMA PET/CT in non-prostate conditions.

Keywords:
18F-FDG PETGCAPSMA PETVasculitis

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