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The Search for an HIV Cure: Where Do We Go From Here?
Jonathan Z Li1, Rajesh T Gandhi2
1Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
The Journal of Infectious Diseases
|February 15, 2021
Summary
Researchers are advancing HIV cure strategies by understanding viral persistence. Despite progress, achieving a safe and accessible treatment for sustained remission remains challenging, requiring new therapeutic approaches.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- Significant advancements in understanding Human Immunodeficiency Virus (HIV) persistence have followed the first reported sterilizing cure.
- However, developing safe and widely accessible treatments for sustained HIV remission remains a critical challenge.
Discussion:
- This supplement reviews the technical hurdles impeding the development of effective HIV remission therapies.
- It highlights essential assays for accurately measuring HIV persistence.
Key Insights:
- Understanding the mechanisms of HIV persistence is crucial for developing cure strategies.
- Next-generation therapeutics are being explored to achieve sustained HIV remission.
Outlook:
- Continued research into HIV persistence and therapeutic development is essential.
- The field aims to overcome current technical barriers to provide broadly available HIV remission treatments.
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