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Subacute structural myopathy associated with human immunodeficiency virus infection
M F Gonzales1, R K Olney, Y T So
1Department of Pathology, University of California, San Francisco 94143.
Archives of Neurology
|May 1, 1988
Summary
This study describes a rare myopathy in two men with human immunodeficiency virus (HIV). The condition involves selective loss of thick filaments and rod body formation, potentially linked to HIV, and responded to steroid therapy or plasmapheresis.
Area of Science:
- Neurology
- Virology
- Pathology
Background:
- Human immunodeficiency virus (HIV) infection can manifest with various neuromuscular complications.
- Myopathies are a known, though less common, complication of HIV.
Observation:
- Two male patients seropositive for HIV presented with an unusual myopathy.
- Histopathological examination revealed selective loss of thick filaments and widespread rod body formation.
Findings:
- This specific combination of morphological abnormalities in HIV-seropositive individuals has not been previously reported.
- The observed myopathy is hypothesized to be related to the underlying HIV infection.
Implications:
- This case report highlights a novel myopathic presentation potentially associated with HIV.
- Successful treatment responses to steroid therapy and plasmapheresis suggest potential therapeutic strategies for this rare condition.