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Updated: Nov 17, 2025

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
Published on: June 24, 2015
M-current induced Bogdanov-Takens bifurcation and switching of neuron excitability class
Isam Al-Darabsah1, Sue Ann Campbell2
1Department of Applied Mathematics and Centre for Theoretical Neuroscience, University of Waterloo, N2L 3G1, Waterloo, ON, Canada.
Abstract:
In this work, we consider a general conductance-based neuron model with the inclusion of the acetycholine sensitive, M-current. We study bifurcations in the parameter space consisting of the applied current [Formula: see text], the maximal conductance of the M-current [Formula: see text] and the conductance of the leak current [Formula: see text]. We give precise conditions for the model that ensure the existence of a Bogdanov-Takens (BT) point and show that such a point can occur by varying [Formula: see text] and [Formula: see text]. We discuss the case when the BT point becomes a Bogdanov-Takens-cusp (BTC) point and show that such a point can occur in the three-dimensional parameter space. The results of the bifurcation analysis are applied to different neuronal models and are verified and supplemented by numerical bifurcation diagrams generated using the package MATCONT. We conclude that there is a transition in the neuronal excitability type organised by the BT point and the neuron switches from Class-I to Class-II as conductance of the M-current increases.
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