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Phytochemicals in thyroid cancer: analysis of the preclinical studies

Stefania Bulotta1, Francesca Capriglione1, Marilena Celano1

  • 1Department of Health Sciences, University "Magna Graecia" of Catanzaro, Viale Europa, Germaneto, 88100, Catanzaro, Italy.

Endocrine
|February 15, 2021
PubMed
Abstract

Insights

Plant compounds show promise for treating thyroid cancer (TC) resistant to current therapies. These phytochemicals exhibit anticancer effects and may help restore iodine uptake, aiding radioiodine treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products

Background:

  • Thyroid cancer (TC) presents challenges, particularly radioiodine-resistant forms.
  • Current treatments for refractory TC are limited, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review preclinical evidence of plant-derived compounds' efficacy against thyroid cancer.
  • To explore phytochemicals as potential single agents or adjuvants for radioiodine-resistant TC.

Main Methods:

  • Literature review of preclinical studies on phytochemicals and thyroid cancer.
  • Analysis of studies reporting antiproliferative effects.
  • Examination of studies assessing iodine retention capabilities.

Main Results:

  • Numerous plant-derived compounds demonstrate significant antiproliferative activity against thyroid cancer cells.
  • Certain phytochemicals show potential to re-induce iodine retention in resistant cancer cells.

Conclusions:

  • Phytochemicals represent a promising avenue for novel thyroid cancer therapies.
  • These compounds may serve as valuable adjuncts to radioiodine treatment in refractory cases.
Keywords:
Combinatory treatmentPhytochemicalsPreclinical studiesThyroid cancer

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