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Updated: Nov 17, 2025
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Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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Cellular senescence and hematological malignancies: From pathogenesis to therapeutics
Dingyu Hu1, Shunling Yuan1, Jing Zhong2
1Department of Clinical Laboratory, The First Affiliated Hospital, University of South China, Hengyang 421001, Hunan, China.
Pharmacology & Therapeutics
|February 15, 2021
Summary
Cellular senescence, a cell cycle arrest, plays a dual role in cancer, preventing and promoting tumor growth. Targeting senescence offers new therapeutic strategies for hematological malignancies.
Area of Science:
- Oncology
- Cell Biology
- Hematology
Background:
- Cellular senescence is a permanent cell cycle arrest induced by stress.
- It plays a complex role in tumorigenesis, potentially preventing or promoting cancer.
- Cellular senescence is implicated in hematological malignancies like leukemia, MDS, and MM.
Purpose of the Study:
- To review the role of cellular senescence in the pathogenesis and development of hematological malignancies.
- To explore potential therapeutic strategies targeting cellular senescence in these diseases.
- To summarize emerging information on cellular senescence in tumorigenesis and clinical applications.
Main Methods:
- Systematic review of existing literature.
- Analysis of the role of cellular senescence in hematological malignancies.
- Investigation of the bone marrow microenvironment's influence.
Main Results:
- Cellular senescence is linked to hematopoietic stem cell decline and increased malignancy risk.
- The senescence-associated secretory phenotype (SASP) in the bone marrow microenvironment promotes tumor growth.
- Therapeutic strategies targeting senescence, including induction and elimination, are being developed.
Conclusions:
- Cellular senescence is a critical factor in hematological malignancies.
- Targeting cellular senescence presents promising therapeutic avenues.
- Understanding senescence mechanisms can guide rational treatment design for these cancers.
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