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Some adverse reactions to allopurinol may be mediated by lymphocyte reactivity to oxypurinol
B T Emmerson1, R A Hazelton, I H Frazer
1Department of Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia.
Arthritis and Rheumatism
|March 1, 1988
Abstract:
Six of 9 patients with previously documented adverse reactions to allopurinol exhibited transformation of their peripheral blood lymphocytes when these were exposed in vitro to the allopurinol metabolite, oxypurinol. In 2 of these subjects, intradermal skin challenge was positive at 48 hours with either allopurinol or oxypurinol. The evidence presented suggests that some adverse reactions to allopurinol represent delayed-type hypersensitivity to oxypurinol.