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Related Concept Videos

Physical Properties of Ethers02:17

Physical Properties of Ethers

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Overview
An ether molecule has a net dipole moment due to the polarity of C–O bonds. Subsequently, boiling points of ethers are lower than those of alcohols of comparable molecular weight and slightly higher than those of hydrocarbons of comparable molecular weight (Table 1).
Ethers can act as hydrogen bond acceptors, making them more water-soluble than hydrocarbons, but since ethers cannot act as hydrogen bond donors, they are much less soluble in water than alcohols. Ethers are considered...
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Intermolecular forces dictate several physical properties such as boiling points, melting points, solubilities, and so forth. They are classified into four types: ionic forces, hydrogen bonds, dipole–dipole forces, and dispersion forces. Ionic forces are the strongest, while dispersion forces are the weakest.
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Physical Properties of Carboxylic Acids01:31

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Carboxylic acids with lower molecular weight exhibit a sharp and unpleasant odor. They also have higher boiling and melting points than analogous compounds, such as aldehydes, ketones, and alcohols.
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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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Types of Step-Growth Polymers: Polyesters01:20

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
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π Molecular Orbitals of 1,3-Butadiene01:24

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Conjugated dienes have lower heats of hydrogenation than cumulated and isolated dienes, making them more stable. The enhanced stabilization of conjugated systems can be understood from their π molecular orbitals.
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Mechanical properties of ester- and ether-DPhPC bilayers: A molecular dynamics study.

Ali Rasouli1, Yousef Jamali2, Emad Tajkhorshid1

  • 1NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, And Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Journal of the Mechanical Behavior of Biomedical Materials
|February 15, 2021
PubMed
Summary

Ether linkages in DPhPC lipid bilayers significantly alter mechanical properties, making them stiffer, thicker, and less ordered than ester counterparts. This study quantizes these mechano-chemical changes using molecular dynamics simulations.

Keywords:
Area compressibility modulusArea per lipidDPhPC bilayersEther linkageMolecular dynamicsStructural stability

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Area of Science:

  • Biophysics
  • Computational Chemistry
  • Materials Science

Background:

  • DPhPC lipid bilayers are crucial for biological studies, drug delivery, and electrophysiology.
  • Their mechanical properties are not fully characterized, especially concerning ether linkages.

Purpose of the Study:

  • To investigate the impact of ether linkages on DPhPC lipid bilayer mechanical properties.
  • To compare ether- and ester-DPhPC bilayers using all-atom molecular dynamics simulations.

Main Methods:

  • All-atom molecular dynamics simulations.
  • Computational frameworks to estimate area per lipid, thickness, pressure profiles, order parameters, and elastic moduli.
  • Comparison with experimental data.

Main Results:

  • Ether linkage significantly stiffens the lipid bilayer compared to ester linkage.
  • Ether DPhPC bilayers exhibit reduced area per lipid, increased thickness, and lower order parameters.
  • Simulated properties show good agreement with available experimental values.

Conclusions:

  • Ether modification profoundly influences the mechano-chemical properties of DPhPC lipid bilayers.
  • The findings provide valuable insights into lipid bilayer mechanics for various applications.