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A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
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Challenges estimating patient organs doses undergoing enhanced chest CT examination: exploratory study.

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Summary

This study found that the Amato

Keywords:
CT-EXPOenhanced chest CThounsfield unitsindividualized dosimetryliver and pancreasorgan dose

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Area of Science:

  • Medical Physics
  • Radiology
  • Radiation Dosimetry

Background:

  • Estimating organ doses (ODs) in computed tomography (CT) is crucial for patient safety.
  • Contrast enhancement in CT can influence organ doses, necessitating accurate estimation methods.
  • Current methods for dose estimation may not fully capture the impact of contrast agents.

Purpose of the Study:

  • To estimate organ doses (ODs) in patients undergoing unenhanced (S1) and enhanced (S2) chest CT.
  • To compare the reliability of CT-EXPO simulation and Amato's phantom-based fitting model (APFM) in estimating dose increments due to contrast.
  • To assess the relationship between Hounsfield Units (HUs) and OD increments.

Main Methods:

  • Retrospective analysis of CT scans from 16 patients (unenhanced and enhanced chest CT series).
  • Organ doses (liver, pancreas) estimated using CT-EXPO simulation and APFM.
  • Hounsfield Units (HUs) quantified using regions of interest (ROIs); regression analysis and statistical tests (Spearman, Wilcoxon) performed.

Main Results:

  • Significant differences in HUs and ODs between S1 and S2 were observed.
  • CT-EXPO showed a higher OD difference than APFM for liver and pancreas.
  • APFM demonstrated a strong correlation (R=0.99) between HUs and OD increments, unlike CT-EXPO (R=0.39-0.05).

Conclusions:

  • CT-EXPO is unreliable for assessing dose impact from contrast enhancement.
  • APFM accounts for contrast enhancement but provides only relative OD increments, limiting clinical utility.
  • Further research is needed for accurate, clinically applicable methods to estimate contrast-enhanced CT organ doses.