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Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
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Modifiable Cardiovascular Risk Factors in Patients With Sporadic Cerebral Cavernous Malformations: Obesity Matters

Bixia Chen1, Dino Saban1, Steffen Rauscher1

  • 1Department of Neurosurgery and Spine Surgery (B.C., D.S., S.R., A.H., L.R., A.S., Y.Z., R.J., K.H.W., U.S., P.D.), University Hospital Essen, University of Duisburg-Essen, Germany.

Stroke
|February 16, 2021
PubMed

Insights

Obesity may increase the risk of cerebral cavernous malformation (CCM) hemorrhage, particularly at presentation. However, obesity and other cardiovascular risk factors did not predict long-term bleeding risk in CCM patients.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Medical Imaging

Background:

  • Cerebral cavernous malformations (CCMs) are vascular malformations that can lead to hemorrhage.
  • Modifiable cardiovascular risk factors are potential contributors to CCM-related complications.

Purpose of the Study:

  • To investigate the association between modifiable cardiovascular risk factors and the risk of hemorrhage in sporadic CCM.
  • To determine if factors like obesity, hypertension, diabetes, hyperlipidemia, and nicotine abuse influence CCM bleeding.

Main Methods:

  • Retrospective analysis of 682 adult patients with sporadic CCM and complete MRI data.
  • Evaluation of intracerebral hemorrhage (ICH) at presentation and during follow-up.
  • Logistic and Cox regression analyses to assess the impact of risk factors on ICH and (re)bleeding risk.

Main Results:

  • Obesity (BMI >30 kg/m²) was significantly associated with intracerebral hemorrhage (ICH) as the initial presentation (OR=1.902, P=0.042).
  • Arterial hypertension, diabetes, hyperlipidemia, and nicotine abuse did not show a significant association with ICH at presentation.
  • None of the evaluated risk factors were independent predictors for cumulative 5-year risk of (re)bleeding.

Conclusions:

  • Obesity emerges as a potential risk factor for cerebral cavernous malformation hemorrhage, specifically at the time of initial presentation.
  • Other common cardiovascular risk factors do not appear to influence the risk of CCM hemorrhage in this cohort.
  • Further research is needed to elucidate the long-term impact of these factors on CCM (re)bleeding events.
Abstract

Keywords:
cavernomacerebral cavernous malformationhemorrhagehyperlipidemiashypertensionmagnetic resonance imagingrisk factors

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