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Venous Thromboembolism in Sickle Cell Disease is Associated with Neutrophilia

Jahnavi Gollamudi1, Shashank Sarvepalli2, Animesh Vadaparti Binf3

  • 1Division of Hematology/Oncology, Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.

Hemoglobin
|February 16, 2021
PubMed

Venous thromboembolism (VTE) in individuals with sickle cell disease is common and portends a poor prognosis. The role of leukocyte count and its subsets on risk of VTE in sickle cell disease are not known. We conducted a retrospective case-control study and analyzed for leukocyte count at the time of VTE and 3 months prior. Leukocyte and neutrophil counts were elevated at the time of VTE (p = 0.003 and p = 0.0006, respectively) and 3 months prior (p = 0.001 and p = 0.0096, respectively) when compared to controls. Baseline leukocytosis and neutrophilia may be associated with subsequent risk for thrombosis in sickle cell disease.

Keywords:
Leukocytosisneutrophiliapredictorssickle cell diseasevenous thromboembolism (VTE)

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