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$MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor$

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Peripheral electrical stimulation to reduce pathological tremor: a review.

Alejandro Pascual-Valdunciel^1,2, Grace W Hoo³, Simon Avrillon^3,4

¹Neural Rehabilitation Group, Cajal Institute, Spanish National Research Council (CSIC), Madrid, Spain.

Journal of Neuroengineering and Rehabilitation

|February 16, 2021

Summary

Peripheral electrical stimulation offers a promising non-pharmacological approach for essential tremor (ET) and Parkinson's disease (PD). This review analyzes its potential for tremor reduction, highlighting the need for standardized methods.

Keywords:

Afferent fibers Electrical stimulation Essential tremor Neural circuitry Parkinson’s disease Stimulation parameters Tremor

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Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

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Published on: September 13, 2015

Area of Science:

Neuroscience
Biomedical Engineering
Rehabilitation Medicine

Background:

Essential tremor (ET) and Parkinson's disease (PD) often require pharmacological or surgical treatments with potential side effects or limited efficacy.
Non-pharmacological interventions, including assistive devices and peripheral electrical stimulation, are being explored as alternatives.
Peripheral electrical stimulation aims to modulate sensorimotor pathways to reduce tremor.

Purpose of the Study:

To conduct a comprehensive review of studies investigating peripheral electrical stimulation for tremor reduction.
To analyze the efficacy, methodologies, and hypothesized mechanisms of peripheral electrical stimulation in ET and PD.
To identify limitations and suggest future directions for this therapeutic modality.

Main Methods:

Systematic review and analysis of 27 studies on peripheral electrical stimulation for tremor reduction.
Examination of stimulation strategies, parameters, electrodes, experimental designs, and outcome assessments.
Discussion of proposed mechanisms underlying tremor reduction.

Main Results:

Peripheral electrical stimulation shows potential for both short- and long-term tremor reduction.
Significant disparities exist across studies in stimulation patterns, experimental designs, and tremor assessment methods.
Standardization of methodology is crucial for comparing results and advancing the field.

Conclusions:

Peripheral electrical stimulation represents a promising intervention for essential tremor and Parkinson's disease.
Further research with standardized methodologies is needed to optimize its application.
Understanding the underlying neural and mechanical principles can guide the development of novel stimulation approaches.