Related Experiment Video
Updated: Nov 17, 2025

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
Lipid Clinics Network. Rationale and design of the EAS global project
Asiiat S Alieva1, Lale Tokgözoğlu2, Kausik K Ray3
1Centre of Atherosclerosis and Lipid Disorders, Almazov National Medical Research Centre, Saint Petersburg, Russia; Department of Pharmacological and Biomolecular Sciences (DisFeB), University of Milan, Milan, Italy.
Insights
Low-density lipoprotein cholesterol (LDL-C) drives atherosclerotic cardiovascular disease. European guidelines recommend lowering LDL-C, but inadequate lipid management persists, prompting the EAS Lipid Clinics Network to standardize care across the EU.
Area of Science:
- Cardiology
- Lipidology
- Public Health
Background:
- Low-density lipoprotein cholesterol (LDL-C) is a well-established causal factor in atherosclerotic cardiovascular disease (ASCVD).
- European guidelines emphasize reducing LDL-C levels through risk stratification.
- Current global lipid management shows suboptimal control of dyslipidemia, potentially due to healthcare system challenges.
Purpose of the Study:
- To address the challenge of standardizing and implementing guideline-based lipid management into clinical practice.
- To establish uniform, EU-wide standards for diagnosing, managing, and treating patients with lipid disorders.
- To create a structured approach through the EAS Lipid Clinics Network.
Main Methods:
- Initiation of the European Atherosclerosis Society (EAS) Lipid Clinics Network project.
- Development of standardized protocols based on the ESC/EAS Guidelines on management of dyslipidaemias.
- Focus on uniform diagnosis, management, and treatment strategies.
Main Results:
- The EAS Lipid Clinics Network aims to create a framework for consistent lipid disorder care.
- The project seeks to improve adherence to established European guidelines for dyslipidemia management.
- Standardization efforts are expected to enhance the control of lipid levels across the EU.
Conclusions:
- Implementing uniform standards is crucial for effective dyslipidemia management.
- The EAS Lipid Clinics Network initiative addresses critical gaps in current lipid care.
- Standardized approaches are necessary to improve cardiovascular outcomes by optimizing LDL-C reduction.
Abstract:
The evidence of the causal role of low-density lipoprotein cholesterol in the development of atherosclerotic cardiovascular disease is well-established. The clearly identified common position of the European guidelines proclaims necessity to decrease LDL-C concentrations based on a proper risk stratification. However, current worldwide situation with the lipid management still demonstrates inadequate dyslipidemia control, that is probably related to a healthcare system issues. As the need to standardize and implement approaches following the guidelines into clinical practice remains a challenge, the EAS initiates the Lipid Clinics Network project, aiming to provide a structure to establish uniform EU-wide standards of diagnosis, management and treatment of patients with lipid disorders, based on the ESC/EAS Guidelines on management of dyslipidaemias.
Related Concept Videos
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Assembly of the Lipid Bilayer in the ER
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipid Digestion
Lipids as Anchors
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...

