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Transient Severe Liver Injury: A Unique Presentation of COVID-19 Disease in a Pediatric Patient

Vasiliki Sgouropoulou1, Euthymia Vargiami, Maria Kyriazi

  • 1From the First Department of Pediatrics, Aristotle University Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.

The Pediatric Infectious Disease Journal
|February 16, 2021
PubMed

Insights

Coronavirus disease 2019 (COVID-19) can cause severe liver injury, even in children with mild symptoms. Prompt recognition of hepatic damage is crucial for effective management in pediatric patients.

Area of Science:

  • Hepatology
  • Virology
  • Pediatric Medicine

Background:

  • Hepatotoxicity is a recognized complication of coronavirus disease 2019 (COVID-19).
  • The spectrum of liver injury in COVID-19 can range from mild transaminitis to severe hepatic dysfunction.
  • Pediatric involvement in COVID-19 has been associated with various clinical manifestations, including liver injury.

Observation:

  • A pediatric case of COVID-19 with a mild clinical phenotype is presented.
  • This patient experienced transient but severe liver injury.
  • The hepatic damage occurred despite the overall mild presentation of the disease.

Findings:

  • Transient severe liver injury can occur in pediatric patients with COVID-19.
  • Liver dysfunction may be present even in mild cases of coronavirus disease 2019.
  • The severity of hepatic damage is not always correlated with the overall clinical severity of COVID-19 in children.

Implications:

  • Healthcare providers should consider hepatic damage in the differential diagnosis of children with COVID-19, irrespective of symptom severity.
  • Early identification and management of COVID-19-related liver injury are essential for improved patient outcomes.
  • Further research is warranted to understand the mechanisms of COVID-19-induced hepatotoxicity in pediatric populations.

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