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A critical period for long-term potentiation in the developing rat visual cortex.

A T Perkins1, T J Teyler

  • 1Neurobiology Department, Northeastern Ohio University College of Medicine, Rootstown 44272.

Brain Research
|January 26, 1988
PubMed
Summary

Rodent visual cortex exhibits a critical period for plasticity, with peak long-term potentiation (LTP) in early development. While supragranular plasticity wanes by day 30, infragranular layers remain plastic into adulthood.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cortical Plasticity

Background:

  • The visual cortex undergoes significant developmental changes.
  • Understanding critical periods is crucial for comprehending neural development and plasticity.
  • Long-term potentiation (LTP) is a key mechanism for synaptic plasticity.

Purpose of the Study:

  • To investigate the critical period for long-term potentiation (LTP) in the rodent visual cortex.
  • To determine the developmental trajectory of plasticity in different layers of the visual cortex.
  • To compare plasticity in supragranular and infragranular layers over time.

Main Methods:

  • Utilized in vitro rodent visual cortical slice preparations.
  • Employed current source density (CSD) analysis to measure potentiation.

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  • Stimulated the subadjacent white matter to induce plasticity.
  • Assessed plasticity at different postnatal ages (second postnatal week, day 30, adulthood).

    • Main Results:

    • Peak LTP potentiation in both supra- (II-III) and infragranular (V) layers occurred during the second postnatal week.
    • By day 30, both supragranular and infragranular layers showed minimal potentiation.
    • In adults, supragranular layers showed no change, while infragranular layers exhibited 177% potentiation.

    Conclusions:

    • Rodent visual cortex displays a critical period for maximum plasticity in both supra- and infragranular layers.
    • Supragranular visual cortex plasticity diminishes by day 30.
    • Infragranular layers retain significant plastic qualities into adulthood.