Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Convergent increases in serotonin 1B receptor binding following ketamine and electroconvulsive therapy: a multi-centre bayesian re-analysis of PET data.

Molecular psychiatry·2026
Same author

Tau Accumulation and Dopamine Transporter Availability in Elderly Adults with Depression.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi·2026
Same author

Sleep-Related Eating Disorder among Japanese Psychiatric Outpatients Receiving Ultra-Short-Acting Benzodiazepine Receptor Agonists: A Cross-Sectional Pilot Study.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi·2026
Same author

Universal and culture-tuned neural codes for vocal emotion: an fMRI MVPA study using Japanese and Canadian voices.

Oxford open neuroscience·2026
Same author

Tau accumulation increases the susceptibility to effective seizures of electroconvulsive therapy.

Translational psychiatry·2026
Same author

Hinoki Cypress Aroma Facilitates Swallowing via Premotor and Hypothalamic Down-modulation: A Randomized Within-subject Crossover fMRI Study.

Dysphagia·2026

Related Experiment Video

Updated: Nov 17, 2025

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
09:13

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

14.6K

Bupropion increases cerebral activation in auditory affective processing: A randomized controlled fMRI study.

Tomoko Hama1, Michihiko Koeda2, Yumiko Ikeda3

  • 1Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan; Faculty of Health Science Technology, Bunkyo Gakuin University, 2-4-1, Mukougaoka, Bunkyo-ku, Tokyo, 113-0023, Japan.

Neuroscience Letters
|February 16, 2021
PubMed
Summary
This summary is machine-generated.

Bupropion enhances brain response to positive emotional voices, particularly in the left insula and right superior temporal gyrus. This antidepressant may improve emotional processing in depression by affecting auditory affective processing.

Keywords:
Affective processingAntidepressantEmotional judgementInsulaPharmacological fMRI

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

598
Functional Magnetic Resonance Imaging fMRI with Auditory Stimulation in Songbirds
13:05

Functional Magnetic Resonance Imaging fMRI with Auditory Stimulation in Songbirds

Published on: June 3, 2013

18.5K

Related Experiment Videos

Last Updated: Nov 17, 2025

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
09:13

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

14.6K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

598
Functional Magnetic Resonance Imaging fMRI with Auditory Stimulation in Songbirds
13:05

Functional Magnetic Resonance Imaging fMRI with Auditory Stimulation in Songbirds

Published on: June 3, 2013

18.5K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Bupropion is an antidepressant known for fewer emotional blunting side effects.
  • Antidepressants can alter brain function in response to facial expressions.
  • Vocal affective processing is crucial for recognizing emotions, but bupropion's effect on this is unexplored.

Purpose of the Study:

  • To investigate the acute effects of bupropion on brain activity during vocal affective processing.
  • To determine if bupropion influences the cerebral response to auditory emotional stimuli.

Main Methods:

  • A randomized, placebo-controlled, within-subject trial involving 16 healthy volunteers.
  • Functional magnetic resonance imaging (fMRI) scans were conducted using placebo or bupropion (150 mg).
  • Participants performed an auditory emotional valence judgment task during fMRI.

Main Results:

  • Bupropion significantly increased activation in the left insula and right superior temporal gyrus when processing emotional voices compared to placebo.
  • Activation in the positive emotional circuit was greater with bupropion in the superior temporal gyrus and middle frontal gyrus.
  • No significant differences in behavioral performance were observed between bupropion and placebo conditions.

Conclusions:

  • Bupropion enhances cerebral responses to affective vocalizations, especially positive ones.
  • This suggests a potential mechanism for bupropion's therapeutic effects in depression.
  • The findings highlight bupropion's role in auditory emotional processing.