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Related Experiment Videos

Selective long-term potentiation in the pyriform cortex.

J S Stripling1, D K Patneau, C A Gramlich

  • 1Department of Psychology, University of Arkansas, Fayetteville 72701.

Brain Research
|February 16, 1988
PubMed
Summary

High-frequency electrical stimulation of the olfactory bulb (OB) enhances inhibitory processes in the pyriform cortex (PC). This long-term potentiation (LTP) in the PC alters information processing, differing from hippocampal LTP.

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Area of Science:

  • Neuroscience
  • Olfactory System Research
  • Synaptic Plasticity

Background:

  • Electrical stimulation of the olfactory bulb (OB) evokes potentials in the pyriform cortex (PC).
  • These potentials include a surface-negative wave (period 1) from lateral olfactory tract activation and a surface-positive wave (period 2) linked to inhibition.
  • Previous research indicates that specific stimulation patterns can induce short- and long-term potentiation (LTP) in brain regions.

Purpose of the Study:

  • To investigate changes in the PC evoked potential following olfactory bulb stimulation designed to induce LTP.
  • To compare the effects of high-frequency stimulation versus low-frequency stimulation on PC evoked potentials.

Main Methods:

  • Male Long-Evans rats were used, with electrodes placed in the OB and PC.

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  • Animals were divided into LTP and control groups.
  • LTP group received high-frequency OB stimulation (100 Hz); control group received low-frequency stimulation (1 Hz), repeated over intervals.

    • Main Results:

    • High-frequency OB stimulation did not alter period 1 of the PC evoked potential, indicating unaffected lateral olfactory tract input.
    • LTP animals showed a significant increase in the amplitude and duration of period 2, reflecting short- and long-term changes.
    • This potentiation of period 2 persisted for at least 32 days and suggests an enhancement of inhibitory processes within the PC.

    Conclusions:

    • Repeated high-frequency OB stimulation induces a persistent alteration in PC information processing.
    • The observed LTP in the PC differs from hippocampal LTP, primarily affecting inhibitory mechanisms.
    • The functional significance points towards an enhancement of inhibitory processes in the pyriform cortex.