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Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge

Elizabeth M Burnette1,2, Erica N Grodin1, Naomi I Eisenberger1

  • 1Department of Psychology, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.

Alcohol and Alcoholism (Oxford, Oxfordshire)
|February 16, 2021
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Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin,...
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