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Updated: Nov 17, 2025
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
A novel 100% aqueous solution near-infrared ratiometric fluorescent CN- probe based on 1,4-dihydropyridines, with a
Longqi Xue1, Rui Wang2, Shaolong Qi3
1College of Chemistry, Jilin University, Changchun, 130021, PR China; Key Laboratory of Lymphatic Surgery Jilin Province, Engineering Laboratory of Lymphatic Surgery Jilin Province, Changchun, 130031, PR China.
Abstract:
1,4-Dihydropyridines are a class of drugs with a wide range of biological activities and pharmacological effects. However, there are few reports on its optical activity, especially its application on fluorescent CN- probe. In this experiment, we designed and synthesized a fluorescent probe based on 1,4-dihydropyridines to detect CN-. Interestingly, the probe exhibited outstanding properties such as 100% water soluble, near infrared, ratiometric, fast response, high selectivity and anti-interference ability for other ions. The color change indicated that the probe can be used for naked eye identification. In particular, the probe showed a super large fluorescent emission peak shift (260 nm). In addition, the reaction mechanism of the probe has been studied by 1H NMR titration, high resolution mass spectrometry and theoretical calculations.
