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Diagnostic value of diffusion-weighted imaging/magnetic resonance imaging for peritoneal metastasis from malignant
Li Dong1, Kuo Li, Taisong Peng
1Department of Medical Imaging, the Third People's Hospital of Datong City, Datong, Shanxi, P. R. China.
Background:
Previous meta-analyses examined either multiple tools for the diagnosis of peritoneal metastases (PMs), but not diffusion-weighted imaging (DWI), or included only 1 tumor type. This study aimed to determine the summary diagnostic value of DWI/magnetic resonance imaging in determining PMs originating from various tumors.
Methods:
PubMed, Embase, and Cochrane library were searched for available papers up to 2019/12. Pooled estimates for sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and accuracy were calculated using random-effects models.
Results:
Ten studies were included and could be used to calculate the pooled sensitivity and specificity. The pooled sensitivity of DWI for PMs was 89% (95% confidence interval [CI]: 83%-93%). The pooled specificity was 86% (95% CI: 79%-91%). When considering only the retrospective studies, the pooled sensitivity of DWI for PMs was 85% (95% CI: 81%-89%). The pooled specificity was 84% (95% CI: 72%-92%). When considering only the studies about gastrointestinal tumors, the pooled sensitivity of DWI for PMs was 97% (95% CI: 68%-100%). The pooled specificity was 86% (95% CI: 69%-95%). No publication bias was observed (P = dd.27).
Conclusion:
DWI magnetic resonance imaging is highly sensitive and specific for the detection of PMs from various abdominal cancers.
Insights
Diffusion-weighted imaging (DWI) magnetic resonance imaging demonstrates high sensitivity and specificity for detecting peritoneal metastases (PMs) across various cancers. This advanced imaging technique is valuable for diagnosing PMs in abdominal oncology.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Previous meta-analyses on peritoneal metastases (PMs) diagnosis excluded diffusion-weighted imaging (DWI) or focused on single tumor types.
- This highlights a gap in understanding DWI's diagnostic performance for PMs from diverse cancers.
Purpose of the Study:
- To evaluate the summary diagnostic accuracy of DWI magnetic resonance imaging (MRI) for detecting PMs.
- To assess DWI's utility in identifying PMs originating from various abdominal malignancies.
Main Methods:
- A systematic literature search was conducted in PubMed, Embase, and Cochrane Library up to December 2019.
- Random-effects models were employed to calculate pooled sensitivity, specificity, and likelihood ratios from ten included studies.
Main Results:
- The pooled sensitivity of DWI for detecting PMs was 89% (95% CI: 83%-93%) and pooled specificity was 86% (95% CI: 79%-91%).
- Analysis of retrospective studies showed 85% sensitivity and 84% specificity.
- Studies focusing on gastrointestinal tumors reported 97% sensitivity and 86% specificity for DWI in PM detection.
Conclusions:
- DWI MRI is a highly sensitive and specific imaging modality for the detection of peritoneal metastases.
- The findings support the use of DWI MRI as a valuable tool for diagnosing PMs in patients with various abdominal cancers.
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