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Published on: August 19, 2021
Sentinel lymph node biopsy in head and neck cutaneous melanomas: A PRISMA-compliant systematic review and
Yingyi Zhang1, Chuanqi Liu1, Zihuai Wang2
1Department of Aesthetic Plastic and Burn Surgery.
Background:
Head and neck melanomas (HNMs) behave differently from cutaneous melanomas in other sites, and the efficacy of sentinel lymph node biopsy (SLNB) for patients with HNMs remains controversial.
Methods:
Studies on prognosis following SLNB were included. The prognostic role of SLNB and other potential predictors were analyzed using pooled relative risk (RR) or hazard ratio (HR).
Results:
Pooled statistics showed that SLNB improved overall survival of HNMs patients (HR = 0.845; 95% CI: 0.725-0.986; P = .032). The positive status of SN was proved as a risk factor of poor prognosis in HNMs (HR = 3.416; 95% CI: 1.939-6.021; P < .001). SLNB did not have significant correlation with lower recurrences (RR = .794; 95% CI: 0.607-1.038; P = .091).
Conclusions:
SLNB is associated with better overall survival and the SN status is a promising risk factor of poor prognosis for HNMs patients.
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