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Multitarget fluorescence in situ hybridization diagnostic applications in solid and hematological tumors
Federica Zito Marino1, Matteo Brunelli2, Giulio Rossi3
1Department of Mental and Physic Health and Preventive Medicine, Pathology Unit, University of Campania Luigi Vanvitelli, Napoli, Italy.
Expert Review of Molecular Diagnostics
|February 17, 2021
Summary
Multitarget FISH (mFISH) enhances precision oncology by enabling simultaneous detection of multiple DNA targets. This review explores mFISH applications in diagnosing various solid and hematological tumors for tailored therapies.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Multitarget FISH (mFISH) allows simultaneous detection of multiple DNA sequences using spectrally distinct fluorophores.
- mFISH is a valuable tool for precision oncology, aiding in tailored therapeutic strategies.
Purpose of the Study:
- To review the applications of mFISH technology in the molecular diagnosis of solid and hematological tumors.
- To highlight the potential of mFISH in clinical practice for improved tumor diagnosis.
Main Methods:
- Review of existing literature on mFISH applications in oncology.
- Discussion of mFISH utility in diagnosing specific tumor types like lung, melanoma, renal, bladder, germ cell tumors, and multiple myeloma.
Main Results:
- mFISH offers advantages in time, cost, and biomaterial preservation for molecular tumor diagnosis.
- The technique is applicable to various solid and hematological malignancies.
Conclusions:
- mFISH is a promising technology for molecular diagnosis in precision oncology.
- While offering benefits, mFISH requires specialized expertise for complex result interpretation.
