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Highly efficient sunitinib release from pH-responsive mHPMC@Chitosan core-shell nanoparticles.

Hessam Jafari1, Gholam Reza Mahdavinia2, Bagher Kazemi3

  • 1Molecular Biology Research Center, Systems Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Sheikh Bahaei Street, Tehran, 1951683759, Iran; Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.

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Summary
This summary is machine-generated.

Researchers developed novel magnetic hydroxypropyl methylcellulose (mHPMC) and chitosan core-shell nanocarriers for anticancer drug delivery. These smart drug delivery systems show pH-sensitive release of sunitinib malate, crucial for targeted cancer therapeutics.

Keywords:
ChitosanSunitinibmHPMCpH-Responsive

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Smart drug delivery systems (DDS) are vital for enhancing anticancer therapeutics.
  • Developing novel nanocarriers with controlled release properties is a key research area.

Purpose of the Study:

  • To synthesize and characterize novel magnetic hydroxypropyl methylcellulose (mHPMC) and chitosan core-shell nanocarriers.
  • To evaluate the drug loading capacity and pH-sensitive release of sunitinib malate from these nanocarriers for anticancer applications.

Main Methods:

  • In situ synthesis of magnetic hydroxypropyl methylcellulose (mHPMC).
  • Fabrication of tripolyphosphate (TPP)-cross-linked chitosan core-shell nanocarriers (mHPMC@Chitosan).
  • Characterization using TEM, SEM/EDS, DLS, XPS, FTIR, TGA, XRD, and VSM; drug release studies at different pH values.

Main Results:

  • High encapsulation efficiency for sunitinib malate (above 86%).
  • pH-sensitive drug release observed, with minimal release at pH 7.4.
  • Sunitinib release rate at pH 4.5 decreased with increasing chitosan content (44% release from high chitosan, 93% from low chitosan over two days).

Conclusions:

  • The developed mHPMC@Chitosan core-shell nanocarriers demonstrate excellent potential for smart anticancer drug delivery.
  • The pH-sensitive nature of these nanocarriers allows for controlled release of sunitinib malate.
  • These findings highlight the significance of these novel DDS in targeted cancer therapeutics.