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Gummatous cutaneous tuberculosis associated with the use of infliximab for Crohn's disease

Lucas Campos Garcia1, Everton Carlos Siviero do Vale1, Maria de Lourdes Ferrari2

  • 1Dermatology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Anais Brasileiros De Dermatologia
|February 17, 2021
PubMed

As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patient treated with infliximab for Crohn's disease, who presented diarrhea, weight loss, abdominal pain, fever, and subcutaneous erythematous nodules that evolved with spontaneous fluctuation and ulceration. With the finding of alcohol-resistant bacilli and Mycobacterium tuberculosis DNA in a cutaneous fragment, through polymerase chain reaction, the diagnosis of gummatous tuberculosis was confirmed, probably secondary to hematogenous dissemination from an intestinal focus.

Keywords:
Crohn's diseaseMolecular target therapySkin tuberculosisTumor Necrosis Factor Receptor-Associated Peptides and Proteins

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