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Antimicrobial resistance in clinical isolates of Ureaplasma spp. from samples in Germany

Roger Dumke1

  • 1TU Dresden, Institute of Medical Microbiology and Hygiene, Dresden, Germany.

Antimicrobial Agents and Chemotherapy
|February 17, 2021
PubMed

Insights

Ureaplasma urealyticum and Ureaplasma parvum are common bacteria. Antibiotic resistance to macrolides, tetracyclines, and fluoroquinolones was low in German strains, with 0%, 4.1%, and 7.1% resistance, respectively.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Ureaplasma urealyticum and Ureaplasma parvum are mollicutes species.
  • These bacteria commonly colonize the human urogenital tract.
  • They are associated with both asymptomatic colonization and symptomatic infections.

Purpose of the Study:

  • To determine the antibiotic resistance patterns of Ureaplasma species.
  • To assess resistance to macrolides, tetracyclines, and fluoroquinolones.
  • To analyze resistance in strains isolated in a German university hospital.

Main Methods:

  • Utilized 170 Ureaplasma strains isolated between 2016 and 2019.
  • Employed a combination of commercial tests and molecular methods.
  • Determined minimal inhibitory concentrations (MICs) for antibiotic susceptibility testing.

Main Results:

  • Observed 0% resistance to macrolides.
  • Recorded 4.1% resistance to tetracyclines.
  • Found 7.1% resistance to fluoroquinolones.

Conclusions:

  • Ureaplasma species show low resistance rates to macrolides, tetracyclines, and fluoroquinolones in this German cohort.
  • The findings provide crucial data for guiding antimicrobial therapy for Ureaplasma-associated infections.
  • Continued surveillance of antimicrobial resistance is essential.

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