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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Cross-reactivity00:42

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Adrenergic Agonists: Therapeutic Uses01:30

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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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Updated: Nov 17, 2025

Measuring Local Anaphylaxis in Mice
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Anaphylaxis Due to Remdesivir.

Brian J Hopkins1, Bonnie C Prokesch2,3

  • 1Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Antimicrobial Agents and Chemotherapy
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Summary
This summary is machine-generated.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes respiratory illness. This virus was first detected in Wuhan, China in December 2019.

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Area of Science:

  • * Virology and Epidemiology
  • * Public Health and Infectious Diseases

Background:

  • * Emergence of SARS-CoV-2 in Wuhan, China in December 2019.
  • * Identification of SARS-CoV-2 as the causative agent of a novel respiratory illness.
  • * Association with severe acute respiratory symptoms and pneumonia.

Discussion:

  • * Global health implications of the SARS-CoV-2 outbreak.
  • * The need for rapid diagnostic and therapeutic strategies.
  • * Understanding the transmission dynamics of novel coronaviruses.

Key Insights:

  • * SARS-CoV-2 is a novel coronavirus responsible for a severe respiratory disease.
  • * The virus was first identified in Wuhan, China.
  • * Pneumonia is a key clinical manifestation.

Outlook:

  • * Ongoing research into SARS-CoV-2 pathogenesis and transmission.
  • * Development of vaccines and antiviral treatments.
  • * Strategies for global pandemic preparedness and response.