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Ultrastructural localization of cisplatin in Ehrlich ascites tumor cells
V Rodilla1, J Pertusa, J A Pellicer
1Department of Animal Biology, University of Valencia, Spain.
Cancer Letters
|March 1, 1988
Abstract:
The incorporation of cis-diammine Dichloro Platinum (II) (cisplatin) on the Ehrlich ascites carcinoma (EAT) cells has been studied in this paper. Ultrastructural study of cells treated 'in vivo' with cisplatin showed that a new treatment with this substance after fixation, blocks uranyl acetate staining with the consequent lack of heterochromatin contrast.