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Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...

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Related Experiment Video

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Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue
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A Human 3D neural assembloid model for SARS-CoV-2 infection.

Lu Wang, David Sievert, Alex E Clark

    Biorxiv : the Preprint Server for Biology
    |February 17, 2021
    PubMed
    Summary

    Pericyte-like cells in brain organoids can be infected by SARS-CoV-2, acting as replication hubs. This finding offers a new model for studying neural infections and the impact of COVID-19 on the central nervous system.

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    Area of Science:

    • Neuroscience
    • Virology
    • Cell Biology

    Background:

    • The central nervous system (CNS) is often affected by SARS-CoV-2, but infection mechanisms are unclear.
    • Brain pericytes are hypothesized as potential entry points for SARS-CoV-2 into the CNS.

    Approach:

    • Researchers developed cortical organoids containing pericyte-like cells (PLCs).
    • These PLC-containing cortical organoids (PCCOs) were infected with authentic SARS-CoV-2 to observe viral entry and replication.
    • PLC functions in vitro, including astrocytic maturation and basement membrane production, were assessed prior to infection.

    Key Points:

    • PLCs within PCCOs were successfully infected by SARS-CoV-2.
    • PLCs acted as viral replication hubs, facilitating the spread of the virus to astrocytes.
    • Infection triggered inflammatory type I interferon responses within the neural tissue.

    Conclusions:

    • PCCOs serve as a novel assembloid model for studying SARS-CoV-2 entry and replication in neural tissues.
    • This model advances the understanding of COVID-19's neurological impact and provides a platform for neural infection research.