Related Experiment Video
Updated: Nov 17, 2025
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Quality metrics for head and neck cancer treated with definitive radiotherapy and/or chemotherapy
Radwa Elsharawi1, Eric Antonucci2, Ammar Sukari3
1Wayne State University School of Medicine, Detroit, Michigan, USA.
Background:
The standardization of quality measures has been key in advancing the aims of the National Quality Forum established to improve health outcomes.
Methods:
The National Cancer Database was used to identify eligible patients. Two quality metrics were evaluated including time to treatment initiation (TTI) and chemotherapy in locoregionally head and neck squamous cell carcinoma (HNSCC).
Results:
TTI was significantly associated with mortality reflected by a hazard ratio (HR) of 1.13 for 60-90 days of TTI (95% CI 1.08-1.17), 1.19 for >90 days of TTI (95% CI 1.13-1.26). Patients with locoregionally advanced HNSCC had an 87% adherence to chemotherapy, which correlated with reduced mortality (HR 0.57; 95% CI 0.55-0.59). Patients treated at high quality centers had a 9% increase in survival (HR 0.91; 95% CI 0.88-0.93).
Conclusion:
We identified that both TTI and chemotherapy for locoregionally advanced HNSCC meet criteria for valid quality metrics potentially suitable for national adoption.
