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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

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A Versatile Fluorescent Sensor Array for Platinum Anticancer Drug Detection in Biological Fluids.

Linda Mitchell¹, Clara Shen¹, Hannah C Timmins²

¹School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.

|February 17, 2021

Summary

A new fluorescent sensor array can detect platinum levels in chemotherapy patients. This technology accurately differentiates platinum from other metals and identifies specific platinum complexes, aiding in treatment monitoring.

Keywords:

cisplatin discriminant analysis fluorescence oxaliplatin sensor array

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Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

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Published on: September 25, 2011

Area of Science:

Analytical Chemistry
Materials Science
Biomedical Engineering

Background:

Platinum-based chemotherapy agents are vital anticancer drugs.
Current methods for detecting platinum in biological fluids are insufficient.
Accurate monitoring of platinum levels is crucial for optimizing cancer treatment.

Purpose of the Study:

To develop a novel fluorescent sensor array for detecting platinum complexes in biological samples.
To assess the array's ability to distinguish platinum from other metals and identify different platinum complexes.
To evaluate the array's performance in monitoring platinum concentrations in cancer patients undergoing chemotherapy.

Main Methods:

A six-sensor fluorescent array was designed and fabricated.
Multidimensional data analysis using linear discriminant analysis (LDA) was employed.
The array's performance was tested with various platinum concentrations in human plasma and a cohort of cancer patients.

Main Results:

The sensor array achieved 100% accuracy in discriminating platinum from other metals.
The array successfully differentiated platinum complexes based on their coordination environments.
The system demonstrated sensitivity to cisplatin and oxaliplatin concentrations and distinguished between patient treatment stages.

Conclusions:

The developed fluorescent sensor array offers a promising tool for quantifying platinum in biological fluids.
This technology can improve the understanding of platinum pharmacokinetics in cancer patients.
The array has the potential to inform personalized chemotherapy dosage adjustments to minimize side effects.