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Related Experiment Video

Updated: Nov 17, 2025

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Rapid developments in lateral flow immunoassay for nucleic acid detection.

Chujun Zheng¹, Kan Wang, Wei Zheng

¹Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai Engineering Research Center for Intelligent diagnosis and treatment instrument, Key Laboratory of Thin Film and Microfabrication Technology (Ministry of Education), Shanghai 200240, China. wk_xa@163.com shulanzcj@sjtu.edu.cn zheng-wei@sjtu.edu.cn ym_cheng@sjtu.edu.cn andrewl1234@sjtu.edu.cn caobo34@sjtu.edu.cn dxcui@sjtu.edu.cn.

|February 17, 2021

Summary

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Lateral flow assays (LFAs) for nucleic acid detection are advancing point-of-care diagnostics. Innovations in isothermal amplification and novel labeling materials enhance sensitivity and quantifiability for rapid, field-deployable testing.

Area of Science:

Biotechnology
Molecular Diagnostics
Point-of-Care Testing

Background:

Lateral flow assays (LFAs) offer rapid, low-resource nucleic acid detection.
Increasing demand for point-of-care diagnostics in various fields.

Purpose of the Study:

Review key advancements in lateral flow nucleic acid tests.
Discuss strategies to enhance sensitivity, quantifiability, and field applicability.

Main Methods:

Integration of isothermal amplification techniques (LAMP, RPA) with LFAs.
Development of novel labeling materials for improved signal detection.
Comparison of methods based on limit of detection, time, and quantifiability.

Main Results:

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Related Experiment Videos

Last Updated: Nov 17, 2025

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Microfluidic Chip Fabrication and Method to Detect Influenza

Microfluidic Chip Fabrication and Method to Detect Influenza

Published on: March 26, 2013

Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds

Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds

Published on: November 13, 2021

Isothermal amplification significantly boosts LFA sensitivity for non-laboratory settings.

Novel labeling materials improve LFA quantifiability and enable portable device analysis.

Current methods show promise for diverse applications including diagnostics and monitoring.

Conclusions:

Lateral flow nucleic acid tests are evolving for enhanced performance.
Future directions include microfluidic integration and combination with CRISPR technology.
These advancements aim for more rapid and accurate molecular diagnostics.