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Auxological dynamics of children with Juvenile Idiopathic Arthritis: a mixed-longitudinal study from Chandigarh,

Anil Kumar Bhalla1, Harvinder Kaur1, Surjit Singh2

  • 1Department of Pediatric Medicine, Child Growth & Anthropology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Anthropologischer Anzeiger; Bericht Uber Die Biologisch-Anthropologische Literatur
|February 17, 2021
PubMed

Insights

Children with Juvenile Idiopathic Arthritis (JIA) show impaired weight and height growth, with systemic JIA causing the most significant growth deficits. Oligoarthritis had the least impact on growth patterns.

Area of Science:

  • Pediatric Rheumatology
  • Growth and Development
  • Child Health

Background:

  • Juvenile Idiopathic Arthritis (JIA) is a chronic inflammatory condition affecting children.
  • Growth patterns in children with JIA can be significantly impacted by the disease and its treatment.
  • Understanding subtype-specific growth trajectories is crucial for clinical management.

Purpose of the Study:

  • To investigate the weight and length/height growth patterns in male and female children diagnosed with Juvenile Idiopathic Arthritis (JIA).
  • To compare growth impairments across different subtypes of JIA: oligoarthritis, polyarthritis, and systemic arthritis.
  • To identify potential gender-specific differences in growth among children with JIA.

Main Methods:

  • A mixed-longitudinal study involving 348 children (1-18 years) with JIA, categorized by subtype.
  • Regular weight and length/height measurements collected over 13 years in a dedicated Growth Clinic.
  • Statistical analyses including unpaired Student's t-test and ANOVA with Bonferroni post-hoc tests were used to assess gender and group differences.

Main Results:

  • All JIA subtypes exhibited regular increases in weight and length/height, but with varying degrees of impairment compared to normal growth.
  • Systemic JIA patients showed the maximum growth impairment, while oligoarthritis patients were least affected.
  • Gender differences in growth were observed, with boys with oligoarthritis being lighter and shorter than girls; trends for polyarthritis were inconsistent, and systemic JIA showed complex height differences by age.

Conclusions:

  • Children with oligoarthritis, polyarthritis, and systemic JIA demonstrate impaired weight and length/height growth compared to the 2000 CDC growth standards.
  • The severity of growth impairment in JIA is closely related to the specific subtype of the disease.
  • Early identification and management of growth issues are essential for children with JIA, considering subtype-specific impacts.

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