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Updated: Nov 17, 2025

New Variations for Strategy Set-shifting in the Rat
Published on: January 23, 2017
Critical examination of current response shift methods and proposal for advancing new methods
Véronique Sébille1, Lisa M Lix2, Olawale F Ayilara2
1UMR INSERM 1246, SPHERE "methodS in Patient-Centered Outcomes and HEalth ResEarch", University of Nantes, University of Tours, Nantes, France. veronique.sebille@univ-nantes.fr.
Current methods for response shift in patient-reported outcomes have limitations. New approaches are needed to accurately capture individual changes over time and improve interpretation of results.
Area of Science:
- Health Outcomes Research
- Psychometrics
- Statistical Modeling
Background:
- Patient-reported outcome measures (PROMs) are crucial in research.
- Response shift can alter the interpretation of PROM results.
- Existing methods for response shift have limitations.
Purpose of the Study:
- To critically examine current methods for response shift.
- To identify limitations of existing response shift methodologies.
- To propose advancements for new response shift methods.
Main Methods:
- Literature review of design-based, qualitative, individualized, and preference-based methods.
- Appraisal of methods based on definition, operationalization, and detection capabilities.
- Evaluation of statistical approaches including latent variable models.
Main Results:
- Eleven methods for operationalizing response shift were examined.
- Six methods differentiate between observed and target change.
- Limitations highlight the need for methods addressing individual variation and multiple time points.
Conclusions:
- No single response shift method is universally optimal.
- Accurate interpretation of results requires additional steps.
- Advancing new methods and conducting comparative simulation studies are recommended.
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